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In our CRISPR screens, we successfully identified known heavy metal transporters, including the metal importer SLC39A14, which mediates the uptake of cadmium in addition to manganese, iron, and zinc (Girijashanker et al, 2008), and the multidrug resistance protein MRP1/ABCC1, responsible for the export of mercuryglutathione and arsenicglutathione conjugates (Leslie et al, 2004

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