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Figure 3 This study represented a milestone since it ended the 10 year development of the concept of using DPP-4 inhibition for glucose-lowering action in type 2 diabetes with a clear proof-of-concept study

Clinical data released at the end of 2025 showed that GLP-1 drugs reduce dialysis patient mortality by 17%

Adverse events leading to discontinuation including hypoglycaemia, vomiting, and diarrhoea were more common with combination regimens [6]

We dont have large randomized trials that look at long term safety, live birth, and health of offspring

The broader industry context is that GLP-1 obesity treatments have moved from specialty-adjacent to primary-care mainstream faster than most capacity planning cycles anticipated

Improve Gut Health A healthy microbiome supports hormones like GLP-1, PYY, and ghrelin