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peer review: 2 approved]

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In the double-blinded Metformin to Augment Strength Training Effective Response in Seniors (MASTERS) trial (203), metformin, despite an increase in AMPK signaling, blunted the exercise-induced hypertrophic response in skeletal muscle in healthy men and women over the age of 65 who took part in a supervised progressive resistance exercise training program over 14 weeks following a 2 week metformin treatment (1700 mg/day, or placebo) (203)

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About Michael Growing up Michael struggled with his weight from a very early age