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Constipation and slow transit in PD alter the fermentation patterns in the colon, potentially leading to increased production of metabolites like TMAO (from protein fermentation) which may aggravate neuroinflammation [167]

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Other intermembrane proteins released into the cytosol such as cytochrome c and Smac/DIABLO, do not promote apoptosis because APAP-induced mitochondrial dysfunction and oxidant stress prevents any apoptotic signaling in hepatocytes [54, 55]

doi: 10.1210/jc.2006-1375, PMID: [DOI] [PubMed] [Google Scholar] 3.Ognjenovic M, Ambrosini GL, Malacova E, Doherty DA, Oddy WH, Handelsman DJ, et al