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Ferroptosis-resistant (top 10%, blue) and ferroptosis-sensitive (bottom 10%, red) indicated

[Epub ahead of print] Yalin S, Bilgili A, Onbasilar I, et al

In primary tumors subjected to indirect immunofluorescence a variable number of tumor cells (2575%) showed positive cytoplasmic labeling after incubation with DSIP antiserum

Several important areas need more research

For example, in order to maintain intracellular redox homeostasis and build a powerful antioxidant defense, cancer cells are typically characterized by high level of antioxidants, especially GSH with a high concentration of 10 mM, which is approximately ten times higher than that in normal cells (Labarrere and Kassab, 2022)

Furthermore, the induction of the Myf5 protein requires amino acid methylation, particularly arginine and cysteine, and ROS could mediate cysteine methylation, which ultimately affects the synthesis of taurine