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The reaction of o-quinones with the thiol group of Keap1 cysteines is an essential mechanism for the activation of the NRF2/ARE axis, regulating and ensuring the appropriateness of redox responses and oxidative signaling factors [165], (Figure 11)

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Cycling Details The 5-on/2-off weekly pattern and 8-on/8-off cycle structure both respect the pulsatile biology of the GH axis

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