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Combined Effect Amplification GHRH + GHRP Synergy Simultaneous activation of two independent receptors (GHRH-R and GHS-R1a) on somatotroph cells produces a 2- to 4-fold amplification of the GH AUC compared to each peptide alone

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This cleavage prevents the formation of A peptides by producing a large soluble fragment, sAPP, and a smaller membrane-bound fragment, C-Terminus Fragment (CTF)