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This finding is particularly significant given the 24% total weight reduction achievedhistorically, greater weight loss often correlates with increased lean tissue catabolism

La participacin de la prdida de peso en los efectos del tratamiento con LIRA en el programa SCALE es variable, encontrndose en torno al 100% en resultados sobre fracciones lipdicas, presin arterial e ndice apnea-hipopnea y alrededor del 30% en los efectos sobre el metabolismo hidrocarbonado, en probable relacin con el efecto incretnico del frmaco20

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If you have a lower dose you can keep yourself from a lot of the possible side effects, plus it is a lot cheaper with lower doses