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Trp is metabolized to Kyn by tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase in the Kyn pathway, and to 5-HT by tryptophan hydrolase (TH) and aromatic amino acid decarboxylase (AAD) in the serotonin pathway (Fig

Microglial activation in chronic neurodegenerative diseases: roles of apoptotic neurons and chronic stimulation

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Since this is a new delivery platform of existing drugs rather than a new drug, the regulatory bodies in many jurisdictions typically have alternative, shorter approval pathways available to drug sponsors that do not require the standard Phase I-III clinical trials for a new drug application