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These neurons project to various brain regions involved in energy balance and reward, including the hypothalamus and VTA

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Ternary complexes of USP14/IMPDH2 with chimeras 300 , 330 , and 329 all containing IU1-248 as the USP14-binding moietywere modeled as described in the Computational Methods section

Shelton JG, Steelman LS, White ER, McCubrey JA