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Consequently, DR may be temporarily worsened, and complications may increase from this acute drop in blood glucose, though the long-term effects may prevent further progression of DR

Applicable Across Sexes: While FDA approval is specific to women, clinical and anecdotal evidence suggest efficacy in men, particularly those inadequately responsive to PDE5 inhibitors

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Arch Endocrinol Metab (2021) 65:4217

If the products gets in to eye rinse with water

So, while there are problems there are also solutions