A spinoff company, Athira Pharma (formalized as M3 Biotechnology before rebranding), was founded in 2011 by PhD student Leen Kawas to commercialize dihexa and a related molecule, ATH-1017 (fosgonimeton)
The compound modulates neuronal activity in the lateral hypothalamus, specifically silencing GABAergic neurons that promote feeding behavior, thereby reducing the drive to consume food while enhancing satiety responses
J Steroid Biochem 1987;27(4-6):11351144
The problem with this is that the body has difficulty absorbing oral glutathione and IV supplementation can be financially prohibitive
Higher mitochondrial metabolism in the neurons result in generation of Complex I dependent hydrogen peroxide and neuronal membranes, rich in polyunsaturated fatty acids, are particularly vulnerable to oxidative stress due to their possession of unsaturated double bonds
doi: 10.1016/j.jhep.2020.06.006 32 KaufmannS