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The FDA is unequivocal that "retatrutide and cagrilintide cannot be used in compounding under federal law." "These are not components of FDA-approved drugs and have not been found safe and effective for any condition," the agency said in drug safety information posted online

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While semaglutide targets a single receptor and tirzepatide targets two, retatrutide is a triple agonist simultaneously activating GLP-1, GIP, and glucagon receptors