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[15] [16] Kava was spread by the Austronesian Lapita culture after contact eastward into the rest of Polynesia

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Higenamine is a chemical found in several plants such as aconite, Annona squamosa, Nandina domestica (sacred bamboo) and others[iv]

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Specifically, a dose of 200 mg/kg SAE demonstrated the most significant benefits, characterized by a marked reduction in reactive oxygen species (ROS) production, an enhancement of antioxidant defenses within the lens, a decrease in lipid peroxidation, a suppression of apoptotic processes, and an increase in cell proliferation