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This decline has led some researchers to speculate that reduced GHK signaling could contribute to age-related impairments in: wound healing tissue repair collagen production While this hypothesis remains under investigation, it helps explain why GHK-Cu supplementationparticularly through topical formulationshas become a focus of dermatologic research

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This pathway signals through Gq-phospholipase C-IP3 cascades, increasing intracellular calcium and promoting GH vesicle exocytosis

PMID 19020706

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Acknowledgements This work was supported by the National Key R&D Program of China (Grant No