Its role is to: Enhance insulin secretion when blood sugar rises Reduce glucagon secretion , lowering blood glucose production Slow stomach emptying , which promotes satiety Reduce appetite , leading to weight loss Since natural GLP-1 breaks down quickly, drug companies created synthetic GLP-1 receptor agonists (like semaglutide in Ozempic/Wegovy) that stay active longer
Studies suggest appetite reduction may begin within a few weeks of starting GLP-1 medications, while meaningful changes in weight metrics may appear after 820 weeks, with continued improvement over 6 months or more
The challenge of medicine is to creatively conceive how biology can be brought to bear to alter these for an individual and the field
[DOI] [PubMed] [Google Scholar] 82.Smith SR, Prosser WA, Donahue DJ, Morgan ME, Anderson CM, Shanahan WR
Lee YL, Liu Y, Ng PY, et al
Specific effects documented in research include proliferation of hair follicle progenitor cells, extension of the anagen (growth) phase of the hair cycle, increased hair follicle size and density, formation of new dermal papilla structures, enhanced wound-induced hair neogenesis, and prevention of follicle miniaturization