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Studies have also shown the potential of the DPP-4 inhibitor alogliptin in increasing production of brain-derived neurotrophic factor (BDNF), leading to decrease toxic release of glutamate [67]

Despite these advantages, concerns were raised in preclinical models and case reports highlighting pancreatic changes and acute pancreatitis, respectively

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Interaction of granule, purkinje and inferior olivary neurons in lurcher chimeric mice

This substantial difference reflects semaglutide's direct action on appetite centers and metabolic regulation

Diabetes management may be particularly challenging in individuals with chronic kidney disease who may be at an increased risk of hypoglycaemia and in whom HbA 1c can be falsely low [276] and in people with gastroparesis and unpredictable rates of food absorption [277]