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Metformin plus tirzepatide is a common clinical combination for type 2 diabetes management

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Many people taking GLP-1 medications experience gastrointestinal (GI) side effects like nausea, constipation, diarrhea, or changes in appetite

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GLP-1 RAs, such as semaglutide and tirzepatide, may also help improve metabolic health in patients with PCOS by promoting weight loss, improving insulin sensitivity, and reducing blood glucose levels ( 4 , 6 , 14 )

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