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Why Receptor Selectivity Should Stay Literature-Based

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Apart from the PPP, two subtypes of isocitrate dehydrogenase (IDH) isoenzymes can also generate NADPH based on their intracellular localization: mitochondrial NADP + -dependent IDH ( Idh2 ), as well as cytosolic and peroxisomal NADP + -dependent ICDH ( Idh1 )

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It is important to distinguish between medication-related fatigue and tiredness resulting from lifestyle changes, underlying medical conditions, or other medications

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