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Schmidt L, Shokraneh F, Steinhausen K, Adams CE

AMPK is often described as the cells energy sensor: it activates when cellular energy levels drop and triggers a cascade of responses aimed at restoring energy balance and promoting cell survival and proliferation

Combination therapies using multiple drugs: one targeting early-stage glutamine catabolism and one targeting the resulting downstream pathway could be an effective way to target glutamine-dependent tumours more specifically by limiting the emergence of compensatory pathways

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GLP-1 medications naturally reduce hunger and thirst signals, so patients may forget to drink enough water throughout the day