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Diagnosis The diagnosis of tinnitus requires a systematic and multidisciplinary approach that integrates patient history, physical examination, neuropsychological assessment, audiometric testing, and specialized tinnitus evaluations

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Paul and Brady also note that various single-nucleotide polymorphisms (SNPs) may influence the efficacy and bioavailability, but that at this time there is neither sufficient clinical research in this area nor are tests for these SNPs commercially available

The primary endpoint will be tested using an ANCOVA model with treatment arm as an independent variable and baseline blood p-tau181 concentration as a covariate