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4e, 3NP treatment induced a progressive motor impairment in the mice that were pre-injected with the inactive mito GCL (E103A), but not in those pre-injected with the wild-type mito GCL

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The indigenous gastrointestinal microflora

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In 3 clinical trials on over 350 constipated adults, they improved 47% of all cases and up to 87% of those due to nerve damage [8, 9, 10]