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Identification and structure-function study of positive allosteric modulators of kainate receptors

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With an extended half-life of ~6 days , a single weekly dose holds therapeutic levels steady between injections [1]

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Diabetic neuropathy LONP1 expression is significantly downregulated in the dorsal root ganglia of experimental diabetic neuropathy model rats, leading to characteristic mitochondrial dysfunction, including reduced ETC complex activity and abnormal protein aggregation

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