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This distinction is maintained throughout the manuscript to avoid conceptual dilution and to clearly differentiate between true circadian entrainment and indirect modulation of circadian function ( Age-related declines in melatonin secretion and signaling have been consistently associated with circadian rhythm dampening, sleep fragmentation, increased oxidative stress, and chronic low-grade inflammation, all hallmarks of biological aging

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If you are aged 55 or over with weight loss and upper abdominal pain, reflux or dyspepsia, as these may require urgent referral under NICE suspected cancer guidelines

In another human study (89 subjects), only 25 subjects had a normal 25-hydroxyvitamin D level (over 30 ng/mL)