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Furthermore, it has been revealed during several pre-clinical and clinical trials that RA-FLS plays a significant role in RA through the manufacturing of receptor activator of NF-B ligand (RANKL), which results in bone erosion through enhanced stimulation of osteoclast formation (Alam et al

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[link] Crawford BC, Sewell J, Golembeski G, Roshan C, Long JA*, Yanofsky MF* (*co-corresponding author), "Genetic control of distal stem cell fate within root and embryonic meristems", Science (2015)

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