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The primary outcome for this study was a change from baseline of the Movement Disorder SocietyUnified Parkinsons Disease Rating Scale (MDS-UPDRS) part III compared to what was measured at 12 months after the trial was initiated

This creates a feedback loop where sensitivity breeds more sensitivity

Similarly, for dual/triple agonists, regulatory agencies will demand evidence of incremental benefit vs risk over existing agents

The blood sugar benefits are excellent, and the weight loss is a meaningful bonus that improves overall diabetes management

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If the method picks up known signals accurately, the signals it finds that are not well-documented clinically deserve attention