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Drug Metab Rev 52:472500

consulting fees from Bayer, AstraZeneca, Boehringer Ingelheim, GSK, Otsuka Pharmaceutical Co

Intestinal adaptation to cold-induced metabolic demand and feeding requires GLP-1R and GLP-2R signalling

However, given the rapid weight change and potential nutritional impact, it is prudent to monitor linear growth and puberty (height, bone age, sexual maturation) in any pediatric patient on these drugs (38, 42)

FDA approval normally follows a formal application supported by adequate evidence for a defined product, dose, route, patient population, manufacturing process, labeling, effectiveness, and safety profile

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