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Cardiovascular Outcomes This section reviews current evidence regarding GLP-1 RAs effects on MACE, PAD, CAD, HF, blood pressure, and AF, with detailed findings of trials and meta-analyses discussed in Tables 1 and 2 Major Adverse Cardiac Events Among Patients with T2DM Strong evidence supports using GLP-1 RAs to reduce MACE among patients with T2DM and established CVD

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However, long-term clinical studies (Phase 4) have not confirmed a heightened risk of bleeding after ghutathione