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The longest duration from the initiation of pembrolizumab or nivolumab to the onset of thyroid dysfunction was 166 or 126 days, respectively

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doi:10.1016/j.molmet.2019.09.010 14

It can activate the expression of brain-derived neurotrophic factor (BDNF), promote synaptic plasticity, enhance learning ability and memory, bringing new hope for the treatment of neurodegenerative diseases and improvement of cognitive function