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The mean dissolution time (MDT) is the sum of different periods of time the drug molecules stay in the matrix before release, divided by the total number of molecules, and is optionally calculated by: MDT=nk 1/n /n+ 1 For example, a linear relationship between the mean dissolution time (MDT) of a formulation or device and the concentration of the gelling agent (e.g., poloxamer) indicates that the active agent is released due to the erosion of the polymer gel (e.g., poloxamer) and not via diffusion

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International Journal of Molecular Sciences, 20(10), 2383

[DOI] [PubMed] [Google Scholar] (177).Skjold-Jrgensen J

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