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Despite high hopes that new agents will soon be added to the few available drugs for the treatment of NASH, antidiabetic agents remain the sole alternative, apart from vitamin E, offering a multi-target and relatively effective approach to the treatment of patients with both NAFLD/NASH and DM2

Those with conditions like type 2 diabetes, high blood pressure, or high cholesterol may also benefit significantly

Side-by-side comparison v3.0 transparency score NexLife: 94/100 (6 of 6 pillars) Sequence (WW Clinic): 76/100 (1 of 6 pillars) Drugs offered NexLife: Compounded semaglutide + tirzepatide Sequence (WW Clinic): Semaglutide + Tirzepatide Pricing model NexLife: Flat $145/mo sema, $186/mo tirz (12-mo plan, dose-independent) Sequence (WW Clinic): $99/mo + meds Clinical model NexLife: MD/DO-supervised, synchronous + async Sequence (WW Clinic): WeightWatchers' clinical arm Pharmacy NexLife: Named 503A & 503B partners Sequence (WW Clinic): Brand via insurance States covered NexLife: Availability varies by state + DC Sequence (WW Clinic): Varies Labs included NexLife: Yes included in monthly Sequence (WW Clinic): Add-on or not included Coaching NexLife: 1:1 fitness coaching + personalized nutrition included Sequence (WW Clinic): Varies by plan Financing NexLife: Klarna and Afterpay accepted Sequence (WW Clinic): Standard card payment Regulatory clarity NexLife: Pre-Rx written disclosure that compounded sema/tirz are not FDA-approved Sequence (WW Clinic): Varies Where Sequence (WW Clinic) wins $99 membership integrates with WeightWatchers behavioral program

Interaction effect of PGC-1 rs 10517030 variants and energy intake in the risk of type 2 diabetes in middle-aged adults

doi: 10.1155/2021/8757996 26 WangSShiJPengYFangQMuQGuWet al