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In the intestinal L-cells, proglucagon is cleaved by the enzyme prohormone convertase 1/3 to produce GLP-1, along with other peptides including GLP-2 and glicentin

No built-in ongoing care

Dose escalation schedules amplify these effects early in therapy and then permit physiological adaptation, which is why many patients see gradual improvement

By week 1216, a man 40+ who trained properly and hit protein targets might be down 1218 pounds on the scale but look like he lost 25 because he preserved muscle while losing fat

Subcutaneous injection sites include the abdomen (at least 5 cm from the navel), anterolateral mid-thigh, and outer upper arm