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In addition, r-sFNDC5 and r-irisin upregulated the transcription of other metabolism-related genes including PRDM16, Cidea, LIPC, and TFAM (Figure 6H)

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It is known that during exercise, energy turnover increases and adrenergic mechanisms play an important role in this regulation [114]

In DNCB-induced AD mouse models, systemic administration of the Vitamin D metabolite calcifediol markedly improved barrier function, evidenced by reduced transepidermal water loss, alleviation of stratum spinosum hyperplasia, and downregulation of the water-channel protein AQP3 [231]

Beil W, Obst B, Sewing KF, Wagner S