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Condensation of the cell membrane without affecting membrane integrity, blistering of the plasma membrane, increased density of the mitochondrial membrane, reduction or disappearance of the mitochondrial crest, and rupture of the mitochondrial outer membrane are typical characteristics of ferroptosis (Figure 1) ( in vivo

Under dual depletion of cystine and GSH, HepG2 cells underwent ferroptosis, characterized by a marked increase in lipid ROS and rescue effects of Fer-1 (Fig

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