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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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Before obvious clinical symptoms appear in AD patients, increased BBB permeability occurs in many brain regions, including the hippocampus, cortex, deep gray matter, and white matter by Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) [146,147,148,149]

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However, the Centers for Medicare & Medicaid Services (CMS) is considering expanding coverage of anti-obesity medications beginning in 2026