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Henry RR, Ratner RE, Stonehouse AH, et al

After each increase, blood levels peak over 24 to 72 hours, when nausea and fullness are most likely to return. These effects usually ease during the four-week hold

Diabetes Obes Metab 20:10401043

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To enhance therapeutic outcomes in IBD, there is an urgent and unmet need to develop novel drug delivery systems that: (1) maintain the beneficial properties of oral administration, such as its non-invasive nature and high patient compliance