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Rapid weight loss, especially in the early stages of treatment, can place stress on the body and temporarily disrupt hormonal balance, leading to more intense cramps or irregular periods

Covalent peptide-drug conjugates are harder to manufacture, characterize, and stabilize than unconjugated peptides

DNA protection by PDS5B-RAD51 against MRN nuclease action Stalled DNA replication forks are susceptible to the action of cellular nucleases such as MRE11 3

PMID: 11041866

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[] MAPK1, the other core target identified in this study, is responsible for the proliferation and survival of epithelial cells