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*Correspondence: Luhua Lai, [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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RNA extraction and quantitative RT-PCT (qRT-PCR) Total RNA was extracted using Trizol reagent (Invitrogen, Carlsbad, USA) according to the standard RNA isolation protocol