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Major Findings: Reviewed the design and rationale of the TRIUMPH and TRANSCEND clinical trial programs

There are several potential reasons for taking smaller GLP-1 doses than the amounts that the U.S

doi:10.3390/biom15060796

Most participants on 8 mg and 12 mg reached major weight loss milestones, including at least 1015% weight loss

In these situations, a health care provider may decide its best to stop treatment altogether

It also delays gastric emptying, inhibits glucagon release from pancreatic alpha cells, causes the proliferation of beta cells, and decreases their apoptosis