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Variants in HLA-DR region can lead to an aberrant presentation of commensal skin microbiota or follicular auto-antigens to CD4 + T-cells facilitating the persistent recruitment of Th17 and Th1 cells into the perifollicular space [55, 60, 61]

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Cytokine-directed interventions Anti-inflammatory cytokine-specific compounds, which are successfully used, for example, in rheumatic diseases, have been tested as alternatives to directly targeting the T or B cell in type 1 diabetes, as briefly summarised below

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