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However, due to aging, stress, diseases, or environmental factors, these antioxidants can decrease over time

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Glutathione is synthesized in two sequential enzymatic reactions: glutamate cysteine ligase (GCL) catalyzes the first, rate-limiting step, and glutathione synthetase couples -glutamylcysteine to glycine in the last step [13]

Figure 1 Prevented from undergoing lysosomal degradation, the meningococcus must face the host defense mechanisms present in the intracellular environment

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