ghk-cu tolerance desensitization tachyphylaxis Attenuation of Response to Repeated Drug Administration: A Proposal for Differentiating and 2021A12 Define the terms “tolerance”

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doi: 10.3389/fmolb.2021.7 47 Coz YatacoA

This premise has been confirmed in animal studies whereby low concentrations of hydrogen peroxide were detected in extracellular fluid, but not in blood, following administration of high dose parenteral vitamin C ( Administration of high dose parenteral vitamin C (i.e., 18 g/kg/d) to murine models has been shown to decrease tumor growth and enhance survival ( Table 4 ) ( N -acetyl cysteine inhibited the anti-tumor effect of high-dose vitamin C administration (Yun et al., 2015)

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