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Clinical research suggests that dose increases spaced several weeks apart reduce the likelihood of side effects and allow stable hormone receptor activation

Fatigue: Some participants reported fatigue, particularly during the early titration period

Appetite goes down

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It is a different treatment strategy

With orforglipron offering additional advantages such as the elimination of strict pre-dosing requirements, potential lower cost, and easier storage, it will be important to see whether these features lead to even greater adherence, says Priya Jaisinghani, a diabetes and obesity medicine specialist at NYU Langone