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With that proof of concept in hand, we then investigated the possibility of combining the peptide/oligourea hybrid approach with the protraction strategy, which consists of functionalizing a peptide with a fatty acid chain to promote its binding to albumin and prolong its in vivo half-life

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The most common side effects of GLP-1 RAs include: Nausea and vomiting Abdominal pain and bloating Indigestion or acid reflux (heartburn) Constipation or diarrhea Weakness during exercise Headache These side effects may be bothersome, but are not dangerous