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Roberts BR, Ryan TM, Bush AI, Masters CL, Duce JA

For instance, Casgevy, based on the CRISPR/Cas9 gene-editing system, was the first successful attempt at disease treatment, promising a one-time treatment for a lifelong effect. However, the complexity of clinical applications and the difficulty of target selection in gene editing have led to long treatment cycles and high costs

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10.1016/j.cmet.2015.12.006 154 PeetersT

Fortunately, if a patient returns to opioid use but hasnt stopped taking Suboxone (or only stopped Suboxone for 1-2 days) then the Suboxone can be safely resumed with minimal chance of precipitated withdrawal

Sridevi et al