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In a 104-week extension (BMI 35 subgroup), mean weight loss reached -30.3% at 12 mg meaning the curve was still descending well past 80 weeks

In the non-diabetes cohort, participants receiving the highest dose of retatrutide (12 mg weekly) achieved a mean body weight reduction of approximately 24% over 48 weeks a figure that substantially exceeds weight loss outcomes reported with currently approved agents at comparable timepoints

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2016;95(17): e3462

I noticed a subtle but definite change in how I approached snacks and meal portions

When these nutrients make contact with L-cells, they trigger a cascade of cellular signals that result in GLP-1 synthesis and secretion