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To shed light on these questions, Sam West, a postdoctoral researcher at the University of Oxford and his co-authors reviewed randomized trials and observational studies on more than 6,000 adults who were overweight or obese and took GLP-1s or older weight-loss medications compared with 3,000 others in behavioural weight management programs

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2001;56(6):M366-72

For researchers comparing these options against other medications, our tirzepatide vs semaglutide dosage comparison shows how the concentration and unit calculations differ between these two GLP-1 medications

The following search algorithm was applied: ((GLP-1 receptor agonist OR glucagon-like peptide-1 receptor agonist OR GIP receptor agonist OR glucose-dependent insulinotropic polypeptide OR liraglutide OR semaglutide OR dulaglutide OR tirzepatide) AND (body composition OR fat mass OR muscle mass OR lean mass OR adiposity OR body fat OR sarcopenia)) AND (clinical trial OR study OR randomized controlled trial OR RCT OR intervention study)

Patients with severe renal impairment need careful monitoring and potential dose adjustments