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Clin Sci (1971) 40:9P.310P

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The dosing rationale was determined from the pharmacokinetic profile of mGIPR-Ab following a single ICV-administered dose (Extended Data Fig

167 Evasion of apoptosis brought about by H 2 S has been attributed mostly to CSE-generated H 2 S mediating the per-sulphidation of key proteins in different signalling pathways: nuclear factor-B (NF-B) in hepatoma cells, 168 the Keap1-transcriptional regulator of NRF2, 169 and the extracellular-signal-regulated kinase (ERK)-activating protein kinase 1

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IGF-1 LR3: Slightly Reduced but Sustained IGF-1R Engagement IGF-1 LR3, by contrast, has slightly reduced intrinsic affinity for IGF-1R compared to native IGF-1