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Hypothetical model of dynamic biomarkers of the Alzheimers pathological cascade

Acknowledgements This work was supported by the National Nature Science Foundation of China (82170830), grants from the 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University (No

GPR101 , an orphan GPCR that is constitutively coupled to G s , has been shown to induce GH secretion through the activation of protein kinase A and protein kinase C in the G s and G q /11 pathways (437)

It is released by the pancreatic islet cells in response to food intake and corresponds to the calories ingested

Rich in antioxidants that help protect cells from oxidative stress

Yet, clinical data are scarce and many of these peptides remain under active scientific investigation