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We also observed that the initial rates of nausea and vomiting for women did not decrease over time for up to two years (Fig

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Each subsequent dose tends to produce milder side effects as the body adapts

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Notably, the STEP (Semaglutide Treatment Effect in People with obesity) trials, which specifically examined body composition, demonstrated substantial weight loss compared with placebo (NCT03548935) [53], and reductions in fat mass and visceral adipose tissue were accompanied by decreases in lean mass, although the proportion of lean mass relative to total body mass increased (NCT04074161) [54]

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